Kinetics of membrane micellization by the hydrophobic polyelectrolyte poly( 2-ethylacrylic acid)

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Kinetics of membrane micellization by the hydrophobic polyelectrolyte poly(2-ethylacrylic acid).

Rates of pH-dependent micellization of multilamellar vesicles by the hydrophobic polyelectrolyte poly(2-ethylacrylic acid) (PEAA) have been measured turbidometrically. This polymer shows a strong ph-dependence in its affinity for phospholipid membranes, binding in increasing amounts as pH is lowered and ultimately solubilizing membranes to form mixed micelles (Tirrell, Takigawa and Seki (1985) ...

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Utilizing the Hydrophobic Polyelectrolyte, Poly(2-Ethylacrylic Acid), for Drug Delivery

The pH-dependent conformational transition of poly(2-ethylacrylic acid) [PEAA] and its interaction with phosphotidylcholine bilayer membranes were investigated. The conformational transition was monitored with fluorescence spectroscopy using pyrene as a probe; the location and breadth of the conforrnational transition was shown to be dependent on the molecular weight and polydispersity of the s...

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Hydrophobic Polyelectrolyte: Surface Activity and Membrane Binding

We have previously observed that the hydrophobic polyeleclyte poly(2-ethylacryfic aad) solubilizes lipid mnembranes in a pH-dependent manner, and we have explited this phenomenon to prepare lipid vesicles that release their contents in response to pH, light, or glucose (Thomas, J. L., and D. A. Tirrell. Acc. Chem. Res. 25:336-342, 1992.) The physical basis for the interacfion between poly(2-eth...

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Ultrafast infrared heating laser pulse-induced micellization kinetics of poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) in water.

The heating-induced micellization of poly(ethylene oxide)-b-poly(propylene oxide)-b-poly(ethylene oxide) (Pluronic PE10300) triblock copolymer chains was studied by ultrasensitive differential scanning calorimetry, laser light scattering, and fluorescence spectrometry with a fluorescent probe, 8-anilino-1-naphthalenesulfonic acid ammonium salt. The critical micellization temperatures obtained f...

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Synthesis of poly(maleimide-co-2-ethylacrylic acid) and its properties of suppressing metastasis and growth of carcinoma.

A series of copolymers is prepared using maleimide and 2-ethylacrylic acid as comonomer. This kind of copolymer shows low toxicity (LD50: 601-798 mg/kg) and significant curative effect on Lewis lung carcinoma and S180.

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ژورنال

عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Biomembranes

سال: 1996

ISSN: 0005-2736

DOI: 10.1016/0005-2736(95)00192-1